Stroke caused by stenosis in the carotid arteries Circulatory System Stroke
Conditions
Interventions
Carotid endarterectomy versus carotid artery stenting
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient in need of some type of carotid artery intervention, with substantial uncertainty about whether to treat with CEA or CAS 2. Carotid artery stenosis with no ipsilateral carotid territory symptoms within the last 6 months 3. Patient fit and willing for follow-up
Exclusion criteria
Exclusion criteria: 1. Previous CEA or CAS in randomised artery 2. High risk of adverse events of trial treatment e.g. inaccessible stenosis 3. Small likelihood of worthwhile benefit e.g. low risk of stroke 4. Patient unable or unwilling to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Peri-procedural hazards (within 30 days) stroke, myocardial infarction and death 2. Long-term hazards (after 30 days) stroke and death | — |
Secondary
| Measure | Time frame |
|---|---|
| Cost-effectivness of CEA and CAS | — |
Countries
Belgium, Bulgaria, Canada, China, Czech Republic, Egypt, England, Estonia, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Japan, Kazakhstan, Netherlands, Norway, Poland, Russian Federation, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, United Kingdom, United States of America
Outcome results
None listed