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Removing caries with chemical agents

Efficacy of different concentrations of bromelain gel in removing carious lesions in primary teeth using the chemical-mechanical caries removal (CMCR) technique: an in vivo study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN21124259
Enrollment
60
Registered
2024-10-22
Start date
2023-06-12
Completion date
Unknown
Last updated
2024-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries Oral Health

Interventions

A total of 60 primary canines were included in this clinical trial. Bromelain gel at concentrations formulated pharmaceutically for this study (10%, 15%, and 20%) was used and compared with 2.4% sodiu

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Healthy children with no systemic diseases, such as diabetes, congenital heart disease, or autoimmune disorders, are generally considered for routine dental care without additional medical considerations. 2. The child's level of behavior was positive and definitely positive according to Frankl’s behavior rating scale. 3. With upper primary canine teeth exhibit class V carious lesions involving dentin on the vestibular surfaces, which do not involve the pulp while all teeth are vital and non-accidental, with no clinical signs of pulp involvement. 4. There are no malformations or developmental abnormalities of the teeth.

Exclusion criteria

Exclusion criteria: 1. History of allergy to any of the materials used 2. Systemic diseases 3. Deep caries involving the pulp 4. Presence of edema or a fistula associated with the decayed tooth

Design outcomes

Primary

MeasureTime frame
The number of applications required for the removal of caries to be completed was recorded and the total time taken was measured using a digital timer

Secondary

MeasureTime frame
Pain and acceptability of the process measured using the Sound, Eye and Motor (SEM) Scale after the end of the treatment

Countries

Syria

Contacts

Public ContactDana Alakkad
dana98akkad@gmail.com+963 (0)50401111

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026