Dengue fever Infections and Infestations Dengue fever [classical dengue]
Conditions
Interventions
Patient data and clinical examination will be documented in case record forms (CRF). Blood samples will be collected according to the following schedule:
1. At presentation:
1.1. Blood sample for haem
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Index cases: 1. All ages, either sex 2. Clinical suspicion of dengue: 2.1. Confirmed fever (i.e. an axillary temperature greater than 38°C at presentation) 2.2. Fever less than 72 hours duration 3. Positive NS1 antigen rapid test (indicative of viraemia) Sample collection around index case: All family members and neighbours
Exclusion criteria
Exclusion criteria: Does not meet inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study dengue pathogenesis by comparing the genetic diversity of virus populations in dengue cases versus infecting mosquitoes and in asymptomatic subjects versus symptomatic cases of different severity | — |
Secondary
| Measure | Time frame |
|---|---|
| To study dengue pathogenesis by: 1. Studying the evolution of dengue virus quasispecies during the course of illness 2. Studying antibody responses, viral load and antigenemia in asymptomatic and symptomatic dengue virus infections of varying severity | — |
Countries
Viet Nam
Outcome results
None listed