Effects of probiotic (BC30) supplementation on exercise-induced muscle damage, perceived recovery and athletic performance

Effects of co-administration of probiotic (Bacillus coagulans GBI-30, 6086) and protein (Casein) on markers of skeletal muscle damage, perceived recovery and athletic performance after an intense single leg training bout

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN21076380

Enrollment

Registered

2015-09-07

Start date

2015-02-23

Completion date

Unknown

Last updated

2023-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Probiotic supplementation Nutritional, Metabolic, Endocrine Probiotic supplementation

Interventions

Healthy, recreationally trained male athletes consume 20g of casein (Control = CON) for 2 weeks (days 1-14), followed by a muscle-damaging exercise bout on day 15, perceptual measures on day 16 (24 ho

Ganeden Biotech Inc., Maryfield Heights, OH) for two weeks (days 25-38). A muscle-damaging exercise bout is then performed on day 39, perceptual measures on day 40 (24 hours post exercise), perceptua

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Normal, healthy individuals 2. Aged between 18-25 years 3. Recreationally Trained Males 4. Must be able to perform required testing

Exclusion criteria

Exclusion criteria: 1. Subjects consuming any ergogenic sports nutrition supplements (incl. creatine, HMB, PA, ATP, carnitine or beta-alanine) at least 4 weeks prior to the beginning of the study. 2. Use of prescription medications (antibiotics, NSAIDs) 3. Use of probiotics or digestive enzymes 4. Smokers 5. Presence of any musculoskeletal, medical, or metabolic contraindications.

Design outcomes

Primary

Measure	Time frame
1. Perceptual measures of recovery [muscle soreness and perceived recovery] will be assessed using the visual analogue scale [VAS]. 2. Markers of muscle damage determined: 2.1. Blood Creatine Kinase (CK) 2.2. Blood Urea Nitrogen (BUN) 2.3. Muscle Swelling (MS) will be assessed via two-dimensional, B-mode ultrasonography (GE, LoGIQ e) to determine muscle thickness of the vastus lateralis (VL) 3. Athletic Performance: 3.1. Single-Leg 1RM (1RM): will be assessed via one repetition maximum testing (1RM) in the one-legged leg press. Three maximal attempts will be allotted with the greatest 1 RM counting for final data. 3.2. Single-Leg Vertical Jump Peak Power (VJPP): will be assessed via maximal vertical jump peak power bout using a Tendo Unit (Trencin, Slovak Republic). Three maximal attempts will be allotted with the greatest peak power counting for final data. Participants will 60 seconds between vertical jump attempts. 3.3. Wingate Peak Power (WPP): will be assessed via Monark Wingate cycle ergometry (Monark™, Vansbro, Sweden). During the cycling test, the volunteer will be instructed to cycle against a predetermined resistance (7.5% of body mass) as fast as possible for 10 seconds.	—

Measure

Time frame

1. Perceptual measures of recovery [muscle soreness and perceived recovery] will be assessed using the visual analogue scale [VAS]. 2. Markers of muscle damage determined: 2.1. Blood Creatine Kinase (CK) 2.2. Blood Urea Nitrogen (BUN) 2.3. Muscle Swelling (MS) will be assessed via two-dimensional, B-mode ultrasonography (GE, LoGIQ e) to determine muscle thickness of the vastus lateralis (VL) 3. Athletic Performance: 3.1. Single-Leg 1RM (1RM): will be assessed via one repetition maximum testing (1RM) in the one-legged leg press. Three maximal attempts will be allotted with the greatest 1 RM counting for final data. 3.2. Single-Leg Vertical Jump Peak Power (VJPP): will be assessed via maximal vertical jump peak power bout using a Tendo Unit (Trencin, Slovak Republic). Three maximal attempts will be allotted with the greatest peak power counting for final data. Participants will 60 seconds between vertical jump attempts. 3.3. Wingate Peak Power (WPP): will be assessed via Monark Wingate cycle ergometry (Monark™, Vansbro, Sweden). During the cycling test, the volunteer will be instructed to cycle against a predetermined resistance (7.5% of body mass) as fast as possible for 10 seconds.

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026