Topic: Musculoskeletal
Conditions
Interventions
Patients awaiting hip replacement will have an additional 30 ml of blood collection pre-operatively. Inclusion in the study will not affect patient care in any way, and the surgical procedure will be
Sponsors
University of Leeds (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Patients with a Charnley hip prosthesis that has been in situ for 10 years
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine released by primary human macrophages from individual patients in response to 100 cubic micrometers of polyethylene. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlation of genotype with clinical outcome of THR surgery 2. Correlation of phenotypic response to cytokine promoter polymorphism genotype 3. Number of patients that are low responders, intermediate responders and aggressive responders to wear particles | — |
Countries
United Kingdom
Outcome results
None listed