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Living well with memory difficulties

Goal-oriented cognitive Rehabilitation in Early-stage Alzheimer's disease: multi-centre single-blind randomised controlled Trial (GREAT)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN21027481
Enrollment
480
Registered
2012-10-16
Start date
2012-10-01
Completion date
Unknown
Last updated
2022-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia Mental and Behavioural Disorders Dementia in Alzheimer disease

Interventions

Participants will be randomised to either cognitive rehabilitation or treatment as usual. The cognitive rehabilitation intervention protocol will consist of 10 weekly sessions followed by 4 maintenanc

Sponsors

Bangor University (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The participant must have an ICD-10 diagnosis of Alzheimer?s disease (AD), vascular dementia, or mixed AD and vascular dementia 2. The participant must be in the early stages of dementia, as indicated by an MMSE score of 18 or above 3. If taking acetylcholinesterase inhibitors, the participant must have been receiving a stable dose for one month prior to trial entry, and there should be no intention to change the dose over the period of participation in the study unless clinically indicated 4. The participant must have a carer who is willing to participate 5. The participant must be able to give informed consent

Exclusion criteria

Exclusion criteria: 1. Participants will be excluded if they have a prior history of stroke, brain injury or other significant neurological condition 2. Participants will be excluded if they are unable to speak English

Design outcomes

Primary

MeasureTime frame
Bangor Goal-Setting Interview

Secondary

MeasureTime frame
For participants with dementia (PwPD) 1. DEMQOL 2. Generalized Self-Efficacy Scale (GSES) 3. Hospital Anxiety and Depression Scale (HADS) 4. Rivermead Behavioural Memory Test (RBMT) story recall sub-test 5. Test of Everyday Attention (TEA) elevator counting and elevator counting with distraction sub-tests 6. Delis-Kaplan Executive Function System (D-KEFS) letter fluency sub-test 7. Client Services Receipt Inventory (CSRI) For carers: 1. Relatives' Stress Scale (RSS) 2. EuroQOL (EQ5D) 3. WHO Quality of Life ? BREF (WHOQOL-BREF)

Countries

United Kingdom, Wales

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 13, 2026