Pharmacokinetic-pharmacodynamic modeling of S(+)-KETamine in healthy volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN20522161

Enrollment

Registered

2007-02-26

Start date

2007-02-01

Completion date

Unknown

Last updated

2019-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ketamine, analgesic Signs and Symptoms Analgesic

Interventions

Infusion of S(+)-ketamine or placebo. There are three infusion schemes: 1. In four subjects there will be two 30-minute infusions of S(+)-ketamine, separated by 30 min

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers 18+

Exclusion criteria

Exclusion criteria: 1. Obesity (Body Mass Index [BMI] more than 30) 2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurological disease; diabetes m.; pyrosis; diaphragmatic hernia) 3. Presence of psychiatric disease 4. History of chronic alcohol or drug use 5. Allergy to study medications 6. Possibility of pregnancy 7. Lactation

Design outcomes

Primary

Measure	Time frame
Analgesia and plasma concentration of ketamine.	—

Secondary

Measure	Time frame
Bowdle scale parameters.	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026