Effects of off pump versus on pump coronary surgery on reversible and irreversible myocardial injury: a randomised trial using cardiovascular magnetic resonance imaging and biochemical markers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN20472718

Enrollment

Registered

2005-07-22

Start date

2002-05-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CABG surgery Circulatory System Coronary diseases

Interventions

Single centre randomised trial comparing off pump (beating heart) versus conventional bypass coronary artery surgery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged less than 75 years 2. Isolated coronary grafting

Exclusion criteria

Exclusion criteria: 1. Age greater than 75 years (ten patients) 2. Ppre-existing Left Ventricular (LV) dysfunction (ejection fraction less than 20% by echocardiogram; four patients) 3. Involvement in other clinical trials (ten patients) 4. Typical MRI contraindications (e.g. pacemaker, severe claustrophobia etc.; total of nine patients) 5. Baseline creatinine more than 200 µmol/L (two patients)

Design outcomes

Primary

Measure	Time frame
1. Left ventricular function at one week post-op 2. LV function at six months post-op 3. Myocardial necrosis post-op	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026