Septic shock/ hemofiltration Infections and Infestations Septic shock/ hemofiltration
Conditions
Interventions
Either standard hemofiltration or Cascade hemofiltration (2 types of membrane evaluated)
Sponsors
Gambro Industries, Clinical Affairs Department (France)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient with a septic shock diagnosed by the medical staff team 2. Patient mechanically ventilated and treated by high doses of catecholamines after adequate fluid administration (superior or equal to 1.0 mg/h of norepinephrine or epinephrine) for more than 120 minutes and <24h Note: Patients with renal failure (treated or not) can be included
Exclusion criteria
Exclusion criteria: 1. Age (years) 85 2. Weight >120 kg 3. Thrombocytopenia 5024h 6. Patient admitted to the Intensive Care Unit (ICU) superior or equal to 7 days before the inclusion criteria 7. Patient with intercurrent disease limiting his/her self-sufficiency (need of help before septic shock) 8. Inclusion (<28 days) in another study interfering with the goals of the current investigation 9. Pregnancy and patient under guardianship 10. Immune compromised patients (e.g., being treated for cancer, treated by immunosuppressors or steroids, AIDS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days without catecholamines at the 28th day of randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rate of decrease of catecholamines during the first 72h 2. Number of days without mechanical ventilation at the 90th day 3. Number of days without Renal Replacement Therapy (RRT) at the 90th day 4. Number of days without ICU requirement at the 90th day 5. Death or survivor status at the 90th day | — |
Countries
France
Outcome results
None listed