Colorectal cancer Cancer Colorectal cancer
Conditions
Interventions
During the enrolment period (from 06 November 6th, 2014 to 31 March 2015), all the eligible population were randomly allocated (ratio 1:1) to be screened with two fecal immunochemical test (FIT) syst
Sponsors
Umbria Region: Prevention, veterinary and food safety
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women 2. Age ranged 50-74 years 3. Resident in Umbria Region 4. Without personal history of colorectal cancer
Exclusion criteria
Exclusion criteria: 1. Personal history of colorectal cancer 2. Participants undergone tests for fecal blood within 2 years 3. Participants undergone sigmoidoscopy or colonoscopy within 5 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Participation rate, measured at 6 months since the invitation, as the proportion of those performing the test of those invited | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Proportion of inadequate tests: measured at the end of the study, as the proportion of samples with inadequate material for the analysis. Laboratory assessment 2. Positivity rate: measured at the end of the study, as the proportion of samples with Hb level above the stipyulated cut-off value (100 ng/ml buffer) over the total number of adequate tests. Laboratory assessment 3. Positive predictive value (PPV): mesasured at the end of the study, as the proportion of subjects detected with a CRC or advanced adenoma over those ubdergoring colonscopy assessment 4. Detection rate (DR) for advanced adenoma and CRC: mesasured at the end of the study, as the proportion of subjects detected with a CRC or advanced adenoma over those who have perfromed the FIT test 5. Number needed to scope (NNScope) to detect one advanced neoplasm (AN: advanced adenoma + CRC):mesasured at the end of the study, as 1/PPV | — |
Countries
Italy
Outcome results
None listed