An assessment of the effects of altering blood pressure on cerebral and systemic haemodynamics in patients with acute ischaemic stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN19958964

Enrollment

Registered

2005-10-28

Start date

2000-01-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischaemic Stroke Circulatory System Cerebral infarction

Interventions

Patients will be randomised to receive intravenous dobutamine or normal saline alone. Dobutamine will be administered at increasing concentrations at 5 minute intervals. Measurements using transcrania

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients of either sex =18 years 2. Proven ischaemic stroke on computed tomography (CT) 3. Stroke onset within 96 hours 4. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Non-ischaemic stroke 2. Unconscious or Scandinavian Neurological Stroke Scale (SNSS) conscious level 180 mmHg or 110 mmHg or <60 mmHg 5. Women of childbearing potential/pregnant/lactating

Design outcomes

Primary

Measure	Time frame
1. The ability of dobutamine to reduce systolic, diastolic and mean arterial BP 2. Safety and tolerability of dobutamine in acute ischaemic stroke.	—

Secondary

Measure	Time frame
90 day modified Rankin, Barthel and mortality.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026