Community-acquired pneumonia Respiratory
Conditions
Interventions
This observational study will compare consented patients with severe acute pneumonia to consented patients with and without lung injury. Once enrolled in the study, the participant will have a broncho
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Admitted to a critical care setting in the Oxford University Hospital Trust 2. Mechanically ventilated for less than 72 h 3. Diagnosis of community acquired pneumonia has been made by the treating physicians based on the following criteria: 3.1. Symptoms and/or signs consistent with a lower respiratory tract infection 3.2. Radiological evidence of new onset consolidation on a chest x-ray or CT scan 4. Aged =16 years 5. Able to consent themselves or declaration obtained from a personal or professional consultee
Exclusion criteria
Exclusion criteria: 1. Previously included in the study 2. Hospital admission in the past 30 days (prior to this current presentation) 3. Long-term resident of a nursing home or other residential care facility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantity and phenotype of lung-derived T-cell populations measured using flow cytometry at a single timepoint within 72 h of the establishment of mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of respiratory failure and other organ failure using the sequential organ failure assessment (SOFA) score during the 90 days following admittance or the period from hospital admittance to discharge | — |
Countries
United Kingdom
Outcome results
None listed