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Using antibiotics during surgery to prevent infections after appendix removal

Role of intraoperative antibiotics wound irrigation in reducing surgical site infection following open appendectomy: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN19878512
Enrollment
388
Registered
2025-05-19
Start date
2023-07-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of surgical site infection in patients who had undergone open appendectomies Surgery

Interventions

The two study arms were: A- Experimental Group (Antibiotic Irrigation Group): Patients in this group underwent open appendectomy with intraoperative wound irrigation performed layer by layer using a

Sponsors

Al-Hadi University College
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 15 to 50 years 2. Diagnosed with acute appendicitis 3. Undergoing open appendectomy 4. Provided informed consent

Exclusion criteria

Exclusion criteria: 1. Diabetes mellitus, heart disease, immunocompromised state 2. ASA Grade III or higher 3. Steroid use 4. Allergy to penicillin or cephalosporins

Design outcomes

Primary

MeasureTime frame
Surgical site infection defined and assessed using CDC criteria at postoperative days 10, 15, and 30.

Secondary

MeasureTime frame
1. Preoperative C-reactive protein and white blood cell counts measured using blood test 2. Postoperative SSI risk measured using the Centers for Disease Control and Prevention (CDC) criteria. Patients were evaluated through clinical examination during postoperative follow up on days 10, 15, and 30 after discharge. 3. SSI incidence measured using patient records up to 30 days post operatively 4. Length of hospital stay (days) from day of surgery to discharge and re-admissions measured using patient records

Countries

Iraq

Contacts

Public ContactMohmood Shuhata
Dp.dentistryb@huc.edu.iq+964 7712057762

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026