Cardiovascualr disease/heart failure/device therapy Circulatory System Heart failure
Conditions
Interventions
All patients schedules for CRT who are suitable candidates are randomised into one of two groups. All patients have baseline tests to include echocardiography, NYHA class assessment, 6-minute walk tes
Sponsors
Papworth Hospital NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients (aged 18 years or older, either sex) limited by symptoms of heart failure (New York Heart Association Class III - IV) 2. Left ventricular ejection fraction (LVEF) of less than or equal to 35% and QRS width of greater than or equal to 120 ms despite maximally tolerated doses of standard heart failure treatment (diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, beta blockers and aldosterone antagonists)
Exclusion criteria
Exclusion criteria: 1. Limiting angina 2. Myocardial infarction within preceding 3 months 3. Significant LV hypertrophy 4. Severe co-morbid illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment defined as greater than 15% reduction in Left Ventricular End Systolic Volume at 6 months follow up | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Improvement in combined endpoint of 6 minute walk test performance, Minnesota Living with Heart Failure Questionnaire and NYHA Class | — |
Countries
United Kingdom
Outcome results
None listed