CELEB: Lung volume reduction in COPD - surgery vs endobronchial valves

The CELEB trial: Comparative Effectiveness of Lung volume reduction surgery for Emphysema and Bronchoscopic lung volume reduction with valve placement

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN19684749

Enrollment

Registered

2016-05-23

Start date

2016-06-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emphysema Respiratory Emphysema

Interventions

Patients will be randomised to either unilateral video assisted thoracoscopic (VATS) lung volume reduction surgery (LVRS) or endobronchial valves (BLVR) placed to achieve lobar occlusion.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults (aged 18 or over) with COPD 2. FEV1 100% predicted, RV>170% predicted) 4. Ex-smoker >3 months 5. MRC dyspnoea score 3 or more 6. CT scan assessed at MDT to have intact interlobar fissures (>90%) and heterogeneous emphysema 7. Provision of informed consent to participate

Exclusion criteria

Exclusion criteria: 1. Smoking within 3 months 2. CT scan shows interlobar fissures are not intact 3. Major comorbidity limiting survival 4. Significant pulmonary fibrosis 5. FEV1 and TLco 7kPa 8. Presence of interlobar collateral ventilation assessed by Chartis system

Design outcomes

Primary

Measure	Time frame
Change in iBODE score (a composite of BMI, FEV1, MRC dyspnoea score and shuttle walk test distance) one year post procedure.	—

Secondary

Measure	Time frame
1. Health related quality of life is measured using the COPD assessment test score (CAT) 2. Physical activity level 3. Change in residual volume (RV) 4. Fat free mass	—

Countries

England, Scotland, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 23, 2026