Health (effects on metabolic health) Nutritional, Metabolic, Endocrine
Conditions
Interventions
Thirty (30) healthy male adults will be recruited to participate in a single-blind cross-over randomized controlled trial (single-centre). Participants will be asked to conduct two experimental trials
Sponsors
Qassim University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy male adults 2. Normal body weight with body mass index (BMI)= ?18 to = 25 kg m-2 3. Body weight stable for previous 4 months
Exclusion criteria
Exclusion criteria: 1. History of eating disorder 2. History of gastrointestinal problems or surgery 3. History of allergy 4. History of chronic illness 5. On any medication 6. Smoking 7. On nutritional supplements 8. Following specific diet 9. Currently taking part in other research 10. Being overweight (> 25 BMI kg/m2) or underweight (BMI < 18 kg/m2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial serum glucose, insulin and triglyceride responses are evaluated in the fasted state and at 30, 60, 90, 120 and 180 minutes after ingestion of date-based or mixed fruit-based nutritional bars. The serum glucose and triglyceride concentrations are assessed using colorimetric reagents, while serum insulin concentrations are assessed using enzyme-linked immunosorbent assay (ELISA) kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Thermic effect of feeding and energy substrate oxidation (carbohydrate and fat oxidation rates) are measured using canopy hood indirect calorimetry (Quark RMR, COSMED) in the fasted state and at 30, 60, 90, 120 and 180 minutes after ingestion of date-based or mixed fruit-based nutritional bar. 2. Antioxidative activity is determined using plasma concentrations of total phenolic content, total antioxidative capacity, malondialdehyde and superoxide dismutase in the fasted state and at 60, 120 and 180 minutes after ingestion of date-based or mixed fruit-based nutritional bar. The plasma concentrations of total phenolic content are assessed using colorimetric reagents, while plasma concentrations of total antioxidative capacity, malondialdehyde and superoxide dismutase are assessed using enzyme-linked immunosorbent assay (ELISA) kits. 3. Appetite is measured subjectively using visual analogue scale (VAS) questionnaires in the fasted state and at 30, 60, 90, 120 and 180 minutes after ingestion of date-based or mixed fruit-based nutritional bars | — |
Countries
Saudi Arabia
Contacts
Public ContactHani Alfheeaid
Outcome results
None listed