A randomised controlled trial to compare the efficacy of three new formulations of Ready-to-Use Therapeutic Food (RUTF) in the treatment of severe acute childhood malnutrition

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN19364765

Enrollment

800

Registered

2006-01-23

Start date

2006-01-27

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe acute malnutrition Nutritional, Metabolic, Endocrine Severe acute malnutrition

Interventions

The initial plan was that after initial in-patient stabilisation with F75 milk, enrolled children would be randomised to one of four different types of RUTF: 1. (Control) Standard, high-milk/peanut ba

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All children suffering from severe acute malnutrition (World Health Organisation [WHO] criteria: less than 70% weight/height and/or oedema) admitted to Moyo Malnutrition Ward, Queen Elizabeth Hospital, Blantyre, Malawi

Exclusion criteria

Exclusion criteria: 1. Children with severe cerebral palsy or obvious dysmorphic syndrome 2. Children less than six months of age or 4 kg weight

Design outcomes

Primary

Measure	Time frame
Nutritional cure (%)	—

Secondary

Measure	Time frame
1. Death rate (%) 2. Rate of weight gain (g/kg/day) 3. Incidence of illness episodes (including diarrhoea) 4. Length of stay in programme (days) 5. Default rate (%)	—

Countries

Malawi

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 2, 2026