Chronic obstructive pulmonary disease Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
Not provided at time of registration
Sponsors
NHS R&D Regional Programme Register - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. 80 non-hypercapnic patients with moderate (forced expiratory volume [FEV] <40%) will be recruited from consultant hospital and community chest clinics. 2. All patients will be receiving optimum medical management and will have been stable for at least 4 weeks prior to their initial assessment.
Exclusion criteria
Exclusion criteria: 1. Hypercapnia (PaCO2 >45 mmHg) 2. Any patient who is unsuitable for magnetic stimulation (pacemakers, artificial heart valves, metal prosthesis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean changes in respiratory muscle strength (cms H2O), respiratory muscle endurance (peak power [cms H2O] and duration [seconds]), shuttle walk distance (metres), Borg scores for breathlessness and CRDQ will be compared between groups using an unpaired t-test or analysis of covariance. Any changes in respiratory muscle strength and endurance will be compared with changes in shuttle walk distance and CRDQ scores using correlation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed