Folate Activity Cognition Trial

The effects of physical activity and vitamin B supplementation on cognitive functioning and psychosocial health of older persons with mild cognitive impairment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN19227688

Enrollment

185

Registered

2005-07-04

Start date

2002-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment (MCI) Mental and Behavioural Disorders Mild cognitive impairment (MCI)

Interventions

Twice weekly brisk walking in a group at moderate intensity and/or daily supplementation with Folic Acid, vitamin B12 and B6. Non-supplement groups receive a placebo supplement

non-walking groups will do stretching and relaxation exercises.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. People aged 70 years or older 2. MCI according to the criteria of Petersen: 2.1. Memory complaint 2.2. Objective memory impairment 2.3. Normal general cognitive function 2.4. Intact activities of daily living 2.5. Not demented 3. Recruited from the community

Exclusion criteria

Exclusion criteria: 1. Diseases interfering with cognition 2. Unable to participate in moderate-intensity physical activity

Design outcomes

Primary

Measure	Time frame
Cognitive functioning.	—

Secondary

Measure	Time frame
1. Psychosocial health status 2. Physical activity 3. Physical fitness 4. Serum homocysteine levels	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 17, 2026