Injury, Occupational Diseases, Poisoning: Traumatic brain injury Injury, Occupational Diseases, Poisoning Traumatic brain injury
Conditions
Interventions
High blood sugar (glucose) levels are common during critical illness and are strongly linked to poor outcome. Large scale study has now demonstrated that strict control of blood glucose with insulin c
Sponsors
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Eligibility
Inclusion criteria
Inclusion criteria: 1. Traumatic brain injury requiring intensive care management with intracranial pressure monitoring 2. Age = 16 years old 3. Absence of exclusion criteria
Exclusion criteria
Exclusion criteria: 1. Insulin Dependent Diabetes Mellitus 2. Life threatening injury (not expected to survive > 48 hrs) 3. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Differences in cerebral monitoring parameters between current 'loose' and intensive glycaemic control periods. Parameters used for comparison will include, cerebral extracellular glucose, lactate, pyruvate, lactate to pyruvate ratio (LP), glutamate and glycerol; brain tissue oxygen (PbO2) and intracranial pressure 2. Glucose levels in each protocol group and the frequency of episodes of hypoglycaemia and hyperglycaemia | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed