Post delivery via emergency caesarean section Pregnancy and Childbirth Single delivery by caesarean section
Conditions
Interventions
This is a randomised double blind study comparing Oxytocin and Carbetocin. For each of the study subjects, the kits containing each study drugs (which are identical) will be prepared according to the
Sponsors
University Malaya Medical Centre (Malaysia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women of 18 years or older with a term (more than 37 weeks period of gestation), singleton pregnancy who will be undergoing an emergency Lower Segment Caesarean Section (LSCS) under regional anaesthesia. An emergency LSCS has been defined as an unplanned LSCS which is performed once labour has commenced or during the process of labour for any reasons indicated. Labour in this context has been defined as documented regular contractions with frequency of at least once in 10 minutes with cervical dilatation of 3cm and more.
Exclusion criteria
Exclusion criteria: 1. Suspected or known coagulopathy 2. Hypersensitivity to the study drugs 3. History of heart disease including 3.1. Cardiac arrhythmia 3.2. Hypertension 3.3. Evidence of liver, renal or endocrine diseases (other than gestational diabetes) 4. LSCS is done under general anaesthesia for any reason 5. Diagnosed placenta praevia 6. Placental abruption 7. Fibroid in pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need for additional uterotonic intervention within 24 hours after LSCS to maintain the adequacy of uterine tone as judged by the attending surgeon and clinician. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Drop in haemoglobin and haematocrit level by 24 hours postoperatively 2. Total estimated blood loss 3. Vital signs 4. Side effects 5. Operating time 6. Need for blood transfusion | — |
Countries
Malaysia
Outcome results
None listed