Detection of palisade vessels as a landmark of the end of Barrett's esophagus (BE)

Detection of PALisade VESsels as a landmark for the distal Barrett?s esophagus in Western population

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18904979

Enrollment

Registered

2014-04-01

Start date

2012-05-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Barrett's esophagus, endoscopy Nutritional, Metabolic, Endocrine Barrett oesophagus

Interventions

Taking biopsies from ?the discordant area? to make a histological diagnosis of BE. Based on realtime endoscopy, endoscopic images and biopsies we try to assess the visibility of palisade vessels and t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18-80 years 2. BE with a minimum length of circumferential/ maximal (C2M2) (segment of minimally 2 cm circumferential Barrett epithelium) as pointed by prior endoscopic examination(s) 3. Subject who agrees to participate, fully understands the content of the informed consent form, and signs the informed consent form

Exclusion criteria

Exclusion criteria: 1. (Previous) biopsies of the most distal 2 cm Barrett esophagus (according to CM-classification) showed high grade dysplasia or esophageal adenocarcinoma (EAC) 2. Prior endoscopic treatment for BE or Barrett?s dysplasia/cancer (e.g. radiofrequency ablation, endoscopic mucosal resection, multi-band mucosectomy 3. Prior surgical invervention for the lower part of the esophagus or the upper part of the stomach 4. Subject being pregnant or planning a pregnancy 5. Esophageal stricture preventing passage of endoscope 6. Subject suffering from unstable psychiatric disorder(s) 7. Subject unable to give the informed consent 8. Uncorrectable clotting disorders, esophageal varices, or other conditions precluding taking biopsies

Design outcomes

Primary

Measure	Time frame
The proportion of patients with visible palisade vessels using white light endscopic imaging and using Narrow Band Imaging (EXERA III endoscopy system)	—

Secondary

Measure	Time frame
1. The proportion of patients with visible PVs with or without air inflation, and in a forward view or a retroflex view 2. The degree of discordance between the location of the proximal ends of the gastric folds and the distal end of the PVs 3. The degree of discordance in the location of the proximal ends of the gastric folds between the condition with and without air inflation 4. The proportion of biopsies containing intestinal metaplasia on histological evaluation among the BE area, the area of discordance (area between the top of gastric folds and distal end of PVs), and the gastric area (area just below the distal ends of PVs) 5. The interobserver agreement for the rates of visualisation of PVs and the top of the gastric folds on each condition	—

Measure

Time frame

1. The proportion of patients with visible PVs with or without air inflation, and in a forward view or a retroflex view 2. The degree of discordance between the location of the proximal ends of the gastric folds and the distal end of the PVs 3. The degree of discordance in the location of the proximal ends of the gastric folds between the condition with and without air inflation 4. The proportion of biopsies containing intestinal metaplasia on histological evaluation among the BE area, the area of discordance (area between the top of gastric folds and distal end of PVs), and the gastric area (area just below the distal ends of PVs) 5. The interobserver agreement for the rates of visualisation of PVs and the top of the gastric folds on each condition

—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026