Randomised controlled trial of the efficacy of adding intravenous benzylpenicillin to intravenous flucloxacillin in the treatment of lower limb cellulitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18890135

Enrollment

Registered

2004-09-30

Start date

2001-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cellulitis Skin and Connective Tissue Diseases Cellulits

Interventions

In non-penicillin allergic patients, after consent they will be randomised to receive one of 2 treatments: 1. Intravenous (IV) flucloxacillin 1g four times a day (qds) and IV benzylpenicillin 1.2 g qd

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Current information as of 23/09/09: 1. Patients with lower limb cellulitis and who require admission 2. Initial diameter of cellulitis >100 mm 3. Able to understand spoken and written english Initial information at time of registration: Patients with lower limb cellulitis and who require admission

Exclusion criteria

Exclusion criteria: Added 23/09/09: 1. Known allergy to the study drugs 2. Known renal or hepatic impairment, 3. Random capillary glucose >13 mmol/l 4. Acute co-existent illness in the affected leg, such as deep venous thrombosis, or wound/abscess requiring operative debridement/ repair.

Design outcomes

Primary

Measure	Time frame
Duration of stay, as determined by the number of 6 hourly doses of antibiotic the patient received prior to discharge.	—

Secondary

Measure	Time frame
Therapy failure rate	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026