FindTrial
Sign In

Study into the effects of ischaemic pre-conditioning (IPC) on ischaemia-reperfusion injury (IRI) in patients with peripheral vascular disease

Study into the effects of ischaemic pre-conditioning (IPC) on ischaemia-reperfusion injury (IRI) in patients with peripheral vascular disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN18883083
Enrollment
Unknown
Registered
2004-09-30
Start date
2003-04-01
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular: Peripheral vascular disease Circulatory System Other peripheral vascular diseases

Interventions

Randomised controlled trial
Laboratory study
Qualitative methodology. Exercise on treadmill until symptoms of reperfusion injury are reproduced. This is preceeded by preconditioning exercises (warm up exercises) in some cases vs no preconditioni

Sponsors

Department of Health
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Study group - volunteers selected from patients with peripheral vascular disease (outpatients) who experience symptoms of claudication; control subjects will be age-matched volunteers.

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

MeasureTime frame
Reduction in complications of reperfusion injury as measured by 1. Metabolites 1.1. Lactate 1.2. Blood pH 1.3. Interleukin 6 (IL-6) 1.4. Heat shock protein (HSP) 1.5. Nitric oxide (NO) 2. Blood constituents 2.1. Activated platelets 2.2. Platelet-leucocyte aggregates—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026