Effects of bimatoprost and latanoprost on ocular hemodynamics in normal tension glaucoma: a randomised trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18873428

Enrollment

Registered

2005-03-21

Start date

2003-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal tension glaucoma Eye Diseases Glaucoma

Interventions

Administration of latanoprost or bimatoprost eye drops.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Progressive normal tension glaucoma patients. Progression was defined as progressive excavation of the optic disc (funduscopic and controlled by the Heidelberg retina tomography [HRT]) and/or progressive visual field loss in the Humphrey perimeter over the last 6 - 12 months.

Exclusion criteria

Exclusion criteria: 1. Treated open angle glaucoma 2. Intraocular pressure greater than 21 3. Non-compliance

Design outcomes

Primary

Measure	Time frame
Ocular perfusion is assessed by Doppler imaging. Primary endpoints are the peak systolic velocity (PSV) and end-diastolic velocity (EDV) in the short posterior ciliary artery.	—

Secondary

Measure	Time frame
Secondary endpoints are: 1. The PSV and EDV in: 1.1. The long posterior ciliary artery, 1.2. The central retinal artery, and 1.3. The ophthalmic artery 2. Resistivity index, pulsatility index and time average velocity (maximum and mean) in all four vessels 3. Intraocular pressure	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026