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Fertility window study in subfertile patients with a desire to learn more about female fertility

Assessment of the fertile window in subfertile patients using the P-type crystallization biomarker in liquid endocervical biopsy: a prospective study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN18705969
Enrollment
45
Registered
2025-09-10
Start date
2022-02-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility Urological and Genital Diseases

Interventions

A prospective study was conducted between February 2022 and February 2023 on 45 subfertile patients who had undergone an infertility study in which the NaProTechnology and the RRM approaches were cons

Sponsors

Clinical Consulting G&E
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 42 Years

Inclusion criteria

Inclusion criteria: 1. Women who wished to be treated using NaPro-Technology and an RRM approach 2. Functional gynecological pathologies that could affect follicular development were considered for treatment, such as hypothyroidism, hirsutism, hyperandrogenemia, luteal-phase defects, delayed maturation of follicular development, polycystic ovary syndrome (PCOS) and other causes such as stress, hyperprolactinemia, or pre-obesity

Exclusion criteria

Exclusion criteria: 1. Patients who required surgery to resolve an infertility problem 2. Any pathology that required more time to resolve, such as premature ovarian failure, azoospermia, hyperprolactinemia secondary to pituitary microadenomas 3. Patients with hyperthyroidism, obesity, or anorexia 4. Pathologies requiring further intervention, either surgical or prolonged medical intervention 5. Myomatous uterus requiring surgical intervention or hyperplasia

Design outcomes

Primary

MeasureTime frame
Hexagonal crystallization pattern type P, measured using endocervical liquid biopsies collected within the fertile window from 3 days before the Peak Day (P Day) until P Day, which is the last day with fertile mucus according to CrMS

Secondary

MeasureTime frame
The final pregnancy outcome is determined by recording a positive urine HCG pregnancy in the patient's medical history, or by confirmation by the patient that she has become pregnant

Countries

Spain

Contacts

Public ContactJosé María Murcia Lora
clinicalconsultinggye@gmail.com+34 (0)619170491

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026