Identifying and validating cognitive profiles in schizophrenia and bipolar disorder

PerfilesMICEmiEZ-TB: protocol for a four-year ambispective multicenter study to identify and validate neurocognitive endophenotype profiles in schizophrenia and bipolar disorder using the MICEmi model

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18662002

Enrollment

900

Registered

2026-04-30

Start date

2027-01-01

Completion date

Unknown

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

This is a four-year ambispective, observational, longitudinal multicenter cohort study structured in three sequential phases, conducted across nine CIBERSAM research groups in eight Spanish National H

ICC =0.85). Phase 2 — Prospective (Months 12–45). A novel multicenter cohort of 900 participants (180 per group: schizophrenia, bipolar disorder, first-degree relatives of schizophrenia patients, firs

(b) fasting peripheral blood sampling for quantification of inflammatory cytokines (IL-6, IL-10, TNF-a)

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Adults aged =18 years 2. Confirmed diagnosis of schizophrenia or bipolar disorder according to DSM-5-TR/ICD-11 (patient groups) 3. Unaffected first-degree relatives (parents, siblings or offspring) of individuals with schizophrenia or bipolar disorder (relative groups) 4. No personal or first-degree family history of mental disorder (healthy control group) 5. Written informed consent provided.

Exclusion criteria

Exclusion criteria: 1. Major neurocognitive disorder or intellectual disability 2. Sensory or language barriers precluding cognitive assessment 3. For relative and healthy control groups: any lifetime diagnosis of a psychotic or major affective disorder.

Countries

Spain

Contacts

Public ContactPatricia;Rafael Correa-Ghisays;Tabarés-Seisdedos

;

patricia.correa@uv.es;rafael.tabares@uv.es+34 605216779;+34963864744

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 16, 2026