Breast cancer Cancer Malignant neoplasm of breast
Conditions
Interventions
1. Imaging investigations (with radiation)
2. Additional portal imaging field and Computed Tomography (CT) scan
3. Insertion of gold breast markers at surgery
Sponsors
Cambridge University Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Histological confirmation of invasive carcinoma 2. Operable unilateral breast cancer requiring breast conservation surgery 3. Patient unlikely to require chemotherapy based on biopsy results 4. Patient characteristics e.g. grade 1-2, aged more than 50 years, oestrogen receptor positive, tumours less than 4 cm
Exclusion criteria
Exclusion criteria: 1. Patients requiring mastectomy: there will be no tumour bed to localise 2. Patients likely to require chemotherapy prior to radiotherapy: we wish to complete the study within six months and chemotherapy patients require six months of treatment before radiotherapy is started. In addition, there is considerable shrinkage of the tumour bed after six months as a consequence of seroma re-absorption and tissue re-modelling, thus the tumour bed would be more difficult to identify in this group of patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean daily displacement in tumour bed centre of gravity expressed as three-dimensional co-ordinates. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mean total displacement in tumour bed centre of gravity during a course of radiotherapy 2. Mean change in tumour bed volume 3. Intra- and inter-observer variability in tumour bed localisation | — |
Countries
United Kingdom
Outcome results
None listed