Age-related macular degeneration Eye Diseases
Conditions
Interventions
The cross-sectional component involves 72 individuals with iAMD. The scotopic MAIA (sMAIA) microperimeter will be controlled with the open perimetry interface (OPI) and a user-friendly app to measure
Sponsors
City, University of London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Intermediate AMD in at least one eye according to the Beckman grading scale (Ferris et al., 2013). The fellow eye can be of any AMD status, including no AMD and late-stage AMD 2. Aged 55-85 years and with the capacity to undertake psychophysical testing (for example, it should have been possible to obtain BCVA in the routine clinical test) 3. Sufficient English language comprehension to enable understanding of the participant information sheet and test instructions 4. ETDRS letter chart BCVA in the study eye not worse than 50 letters (6/30 Snellen VA equivalent)
Exclusion criteria
Exclusion criteria: 1. Ocular pathology in the study eye (or in either eye for genetic conditions), other than age-related macular degeneration, which may affect visual function 2. Van Herick grade 24 mmHg 4. Unable to classify AMD grade or to obtain clear OCT image 5. Lens opacity greater than grade 2 on any LOCS III criterion, or other media opacity/nystagmus that might interfere with quality retinal imaging. 6. Diabetes or other significant systemic disease or medication known to affect visual or retinal function 7. Health condition or other reason to make it unlikely that attendance at the follow-up appointment at 12 months would not be feasible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of the second component of rod-mediated dark adaptation (compared between feature-bearing and non-feature-bearing retinal locations) This will be measured at baseline (again within 2 weeks for those participating in the repeatability study) and 12 months. This will be extracted from modelled threshold data from the scotopic MAIA microperimeter and expressed as log units/minute. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The time constant of cone-mediated dark adaptation. This will be measured at baseline (again within 2 weeks for those participating in the repeatability study), and 12 months. This will be extracted from modelled threshold data from the scotopic MAIA microperimeter, and expressed as minutes. 2. The area under the contrast sensitivity function, measured in log units. This will be measured at baseline (again within 2 weeks for those participating in the repeatability study) and 12 months. The data will be extracted from the PopCSF software (Elfadaly et al. 2020). | — |
Countries
England, United Kingdom
Contacts
Public ContactAlison Binns
Outcome results
None listed