Effect of two different volumes of blood transfusion on cardiac function, cerebral and gut hemodynamics in neonates: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18526805

Enrollment

Registered

2006-09-29

Start date

2004-10-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal Diseases Neonatal Diseases

Interventions

After taking informed consent the Ultrasonographic and Doppler assessment of cerebral flow, gut flow and cardiac function, would be done 4 hours before, and 4 and 24-30 hours after transfusion. Block

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Babies admitted to the neonatal intensive care unit and requiring blood transfusion (packed cells) as per the unit protocol and guidelines will be eligible for the study.

Exclusion criteria

Exclusion criteria: 1. Babies with pneumothorax, pneumomediastinum or pneumoperitoneum during study 2. Hypotension requiring changing ionotropic support at time of transfusion 3. Terminally ill babies 4. Complex congenital heart disease 5. Major congenital anomalies

Design outcomes

Primary

Measure	Time frame
1. Effect of blood transfusion 2. Change in cardiac output post transfusion	—

Secondary

Measure	Time frame
1. Change in gut flow 2. Change in cerebral flow 3. Effect on Hemoglobin concentration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026