Deep brain stimulation for severe obsessive compulsive disorder

Deep brain stimulation for severe obsessive compulsive disorder: efficacy and mechanisms of ventral striatum and subthalamic nucleus targets

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18430630

Enrollment

Registered

2015-04-22

Start date

2013-01-22

Completion date

Unknown

Last updated

2020-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Mental Health

Interventions

1. Cognitive Behavioural Therapy: CBT for OCD including Graded Exposure and Self Imposed Response Prevention 2. Deep Brain Stimulation: A neurosurgical procedure involving the implanta

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The inclusion criteria have been designed to be consistent with previous OCD DBS studies and to ensure that patients have not responded in a useful and sustained manner to either modifications of medication or any form of CBT 1. Patients must have undergone intensive treatment and have demonstrable treatment resistance as defined by: 1.1. At least two SRIs for a minimum of 12 weeks at optimal British National Formulary (BNF) doses 1.2.Augmentation of SRI treatment with antipsychotic drugs administered at maximally tolerated doses or by extending the SSRI dose beyond BNF limits 1.3. Two trials of CBT of at least 10 hours 1.4. Failed inpatient treatment 2. Patients must also satisfy the following criteria: 2.1. Age > 20 years 2.2. Confirmation of a primary diagnosis of obsessive compulsive disorder (ICD10 F42.0—F42.9) 2.3. Duration of illness of at least 10 years 2.4. At least 2 years of unremitting symptoms despite intensive psychopharmacological and psychological treatment or failure to sustain, over a 3 month period, a response to inpatient psychological treatment by at least 33% with accompanying optimised pharmacological therapy 2.5. A minimum score of 32 on Yale Brown Obsessive Compulsive Scale (YBOCS 22) thus constituting profound illness and a maximum score of 50 on the DSM IV General Assessment of Function Scale (GAF) 2.6. Ability to provide sustained informed consent

Exclusion criteria

Exclusion criteria: 1. Current diagnoses of substance misuse (ICD10 F10—F19), organic brain syndrome (ICD10 F00—F09), adult personality disorder (ICD10 F60—F69), pervasive developmental disorder (ICD10 F84); schizophrenia (ICD10 F20-F29) and bipolar disorder (ICD 10 F30-31) 2. Contraindications to neurosurgery 3. Pregnancy

Design outcomes

Primary

Measure	Time frame
YBOCS improvement greater than or equal to 35%; Timepoint(s): 15 months	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026