The relationship between the shape of face and size of the airway in subjects with obstructive sleep apnoea syndrome

The relationship between facio-cervical phenotyping and upper airway morphology in obstructive sleep apnoea-hypopnoea syndrome: A 3-dimensional approach

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18399406

Enrollment

132

Registered

2016-02-19

Start date

2016-04-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) Respiratory Obstructive sleep apnoea-hypopnoea syndrome (OSAHS)

Interventions

Interventions as of 02/06/2016: In the first study visit, both obstructive sleep apnoea-hypopnoea syndrome (OSAHS) diagnosed participants and suspected non-OSAHS participants will comp

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. 40 to 65 years old males 2. Clinically normal weight (BMI 30Kg/m2) 3. Caucasian 4. Confirmed diagnosis of OSAHS in the study group and no clinically demonstrable OSAHS in control group 5. Dentate 6. The skin over the face and neck must be free of significant hair.

Exclusion criteria

Exclusion criteria: 1. Edentulous subjects or the absence of 8 or more teeth in each dental arch 2. Facial neuromuscular disorders, craniofacial deformity or history of craniofacial surgery 3. Overweight subjects (BMI between 25 and 30 Kg/m2)

Design outcomes

Primary

Measure	Time frame
Facio-cervical morphology (phenotype)measured using image analysis software for stereophotogrammetry scan, lateral cephalometric radiograph, and cone-beam computed tomography (CBCT) at the second visit after baseline assessment.	—

Secondary

Measure	Time frame
1. The correlation between the surface and skeletal facio-cervical morphology and upper airway dimensions using correlation analysis after the second visit 2. Potentially identifying a facio-cervical marker for OSAHS subjects using multiple regression analysis after the second visit	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026