Subacromial hyaluronic acid injections perform better when combined with exercise-based rehabilitation in the treatment of subacromial impingement syndrome

Comparison between isolated hyaluronic acid injection therapy and combined physical therapy in the treatment of chronic rotator cuff tendinopathy. A randomized prospective clinical study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18380042

Enrollment

160

Registered

2024-11-21

Start date

2011-07-01

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subacromial impingement syndrome Musculoskeletal Diseases

Interventions

Patients selected for the study were carefully informed of the expected benefits of the procedures involved. Patients who accepted our invitation to be enlisted in the study signed a disclosure agreem

15 mg/ml

Anika Therapeutics Inc., Bedford, MA), supplied as sterile, pre-filled syringes. Injections were administered in aseptic conditions with a 21-gauge needle by an experienced physician unaware of the pa

furthermore, they underwent a program of five sessions per week of supervised EBR for a total of 20 treatment sessions in a month. Patients were instructed to avoid any additional therapeutic measure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older 2. A diagnosis of SIAS grade I or II according to Neer’s classification as diagnosed on clinical examination and imaging studies

Exclusion criteria

Exclusion criteria: 1. Calcific tendonitis of the rotator cuff and full-thickness rotator cuff tear 2. Shoulder stiffness 3. Previous fractures and/or surgeries to the same shoulder 4. Long-lasting history of shoulder pain (exceeding 6 months) treated with steroids or NSAIDs 5. Treatment of shoulder pain by EBR or shoulder injections with HA or steroids during the last 6 months 6. Shoulder involvement in congenital or acquired inflammatory or neurological disorders 7. Cognitive or psychiatric impairment 8. Unwillingness or inability to sign informed consent

Design outcomes

Primary

Measure	Time frame
Disease-specific health-related quality of life (QoL) measured using the nationally validated versions of the DASH (Disability of Arm, Shoulder, and Hand) questionnaire in its short version (Quick-DASH) at 1, 3, and 6 months	—

Secondary

Measure	Time frame
Working capacity measured using the DASH work module (Work-DASH) and a functional assessment of the shoulder with the Constant-Murley score (CMS) at 1, 3, and 6 months	—

Countries

Italy

Contacts

Public ContactGiuseppe Milano

giuseppe.milano@unibs.it+39 030 393981

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026