Right ventricular myocardial deformation parameters in patients with congenital heart defect comparison between patients with transposition of the great arteries and patients with Fallot anomaly: Can myocardial deformation parameters predict patients exercise capacity?

Cardiac Magnetic Resonance derived right ventricular myocardial deformation parameters in patients with the systemic pressure loaded right ventricle, comparison between patients with Transposition of the Great Arteries and patients with Fallot anomaly: Is it possible to predict patients ventricular exercise capacity based on myocardial deformation parameters and does it differ depending on the right ventricular pressure load?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18376089

Enrollment

Registered

2017-10-30

Start date

2013-10-02

Completion date

Unknown

Last updated

2023-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Two group of patients with congenital heart disease are included in the study. Patients with the D-transposition of the great arteries (D-TGA) and patients with Fallot anomaly. The main difference between patienst is the pressure load of the right ventricle. In patients with the D-TGA, the right ventricle is situated in the systemic position which means that it is exposed to systemic pressure. In patients with the Fallot anomaly, volume overload is the most common type of overload in this group

Interventions

Two group of patients with congenital heart disease are included in the study: participants with the D-transposition of the great arteries (D-TGA) and participants with Fallot anomaly. The main differ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Congenital heart defect in form of transposition of the great arteries or Fallot anomaly 2. Older then 18 years

Exclusion criteria

Exclusion criteria: 1. Claustrophobia 2. Implanted pace-maker 3. Arrhythmia interfering with image acquisition on CMR

Design outcomes

Primary

Measure	Time frame
1. Strain (longitudinal and radial) is measured using a feature tracking software (2D-Cardiac Performance Analysis version 1.2 Tom Tec Imaging Systems Germany). Global longitudinal strain provided by the software was calculated as the average value of 6 segments in the left ventricle and 6 segments in the right ventricle, from the 4-chamber view. 2. End diastolic and end systolic volume of the left end right ventricle is performed on a workstation equipped with a semiautomatic software for cardiac analysis,” Segment”, designed for volumetric analysis. CMR collected volumes and for both ventricles were derived from short axis slices after manually tracing the endocardial borders excluding the papillary muscles. End diastole and end-systole were defined as the frames with the largest and the smallest ventricular slice area in relation to the ECG and the opening and closure of the aortic and atrioventricular valves. In case of discrepancies (e.g. long QRS duration in case of RBBB or LBBB morphology) the size of the ventricular area was the determining factor. Ejection fraction was then calculated by the program based on the measured volumes. 3. Maximal workload in Watt, peak oxygen uptake, ventilatory gas value (oxygen and carbon dioxide) and maximal heart rate are measured using a electrically braked stationary cycle ergometer Yaeger Oxycon. 4. End diastolic, end systolic volume and longitudinal strain of both left and right ventricle are measured off line using TomTec Imaging system for 4D RV volume calculations	—

Measure

Time frame

1. Strain (longitudinal and radial) is measured using a feature tracking software (2D-Cardiac Performance Analysis version 1.2 Tom Tec Imaging Systems Germany). Global longitudinal strain provided by the software was calculated as the average value of 6 segments in the left ventricle and 6 segments in the right ventricle, from the 4-chamber view. 2. End diastolic and end systolic volume of the left end right ventricle is performed on a workstation equipped with a semiautomatic software for cardiac analysis,” Segment”, designed for volumetric analysis. CMR collected volumes and for both ventricles were derived from short axis slices after manually tracing the endocardial borders excluding the papillary muscles. End diastole and end-systole were defined as the frames with the largest and the smallest ventricular slice area in relation to the ECG and the opening and closure of the aortic and atrioventricular valves. In case of discrepancies (e.g. long QRS duration in case of RBBB or LBBB morphology) the size of the ventricular area was the determining factor. Ejection fraction was then calculated by the program based on the measured volumes. 3. Maximal workload in Watt, peak oxygen uptake, ventilatory gas value (oxygen and carbon dioxide) and maximal heart rate are measured using a electrically braked stationary cycle ergometer Yaeger Oxycon. 4. End diastolic, end systolic volume and longitudinal strain of both left and right ventricle are measured off line using TomTec Imaging system for 4D RV volume calculations

—

Secondary

Measure	Time frame
There are no secondary outcomes.	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026