Does mouthrinsing and gargling with povidone iodine and hydrogen peroxide reduce the number of SARS-CoV-2 viruses in patients with no and mild symptoms?

The evaluation of povidone iodine and hydrogen peroxide mouthrinsing and gargling on CT value of SARS-CoV-2: a randomized controlled trial in asymptomatic and mild symptomatic patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18356379

Enrollment

Registered

2022-02-03

Start date

2021-07-01

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection) Infections and Infestations

Interventions

Research subjects were given mouthrinsing and gargling protocol education through video conference and given mouthrinse that had been repackaged. The 1% povidone iodine group rinsed with BETADINE® Mou

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients of Persahabatan Central General Hospital, (COVID-19 national referral centre) 2. Patients infected with SARS-CoV-2 and identified through RT-PCR with positive results at Persahabatan Central General Hospital during 1st July – 30th September 2021 with CT values = 30 3. Asymptomatic patients or with mild symptoms 4. Patients being diagnosed with COVID-19 for less than three days 5. Aged 19 - 60 years old

Exclusion criteria

Exclusion criteria: 1. Patients not willing to be research subjects 2. Patients with comorbid and thyroid diseases 3. Pregnant patients 4. Patients routinely consumed lithium drugs 5. Patients undergoing radioactive iodine treatment 6. Patients allergic to povidone iodine and hydrogen peroxide

Design outcomes

Primary

Measure	Time frame
Viral load measured using CT value of the RT-PCR examination on day 1, day 3 and day 5 after the mouthrinsing and gargling intervention	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Indonesia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026