How does hyalobarrier gel influence ovulation and pregnancy outcomes in women with scarring around the tubes and ovaries?

Randomsied controlled trial of hyalobarrier versus no hyalobarrier on the ovulatory status of women with peri-ovarian adhesions: a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18335881

Enrollment

Registered

2016-09-14

Start date

2012-02-01

Completion date

Unknown

Last updated

2016-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adnexal adhesions Pregnancy and Childbirth Adnexal adhesions

Interventions

Participants are randomised to one of two groups using a computer generated random numbers table and opaque envelopes. Intervention group: Participants receive hyalobarrier get at laparoscopy. This i

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Aged between 18-38 2. Women were undergoing operative laparoscopy for gynaecological pathology, with possible peri-ovarian adhesions

Exclusion criteria

Exclusion criteria: 1. Presence of malignancies or a history of malignancies 2. Women on medications that affected ovulation 3. Women with known conditions that resulted in anovulation (PCOS, Pituitary causes)

Design outcomes

Secondary

Measure	Time frame
Clinical pregnancy is measured by the presence of a fetal heart at 5-6 weeks gestation.	—

Primary

Measure	Time frame
Ovulatory status is measured using serum hormonal status (Day 2 FSH, LH and Day 21 progesterone) prior to the surgery and at 3 and 6 months after the surgery. Post-operatively, the participant will also undergo a follicular tracking cycle at 3 and 6 months.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026