Obesity Nutritional, Metabolic, Endocrine
Conditions
Interventions
Control:
1. Reduce physical activity to < 4000 pedometer steps per day for 7 days
2. Increase energy intake by 50% above normal for 7 days
Intervention
Sponsors
University of Bath (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Males 2. Aged between 18-40 years 3. Active - exercise more than 30 minutes per day, at least three times per week 4. Stable weight in the last six months- changes in fat mass might influence some of the outcome measures
Exclusion criteria
Exclusion criteria: 1. Females 2. Smoker 3. Aged less than 18 years or greater than 40 years. 4. Positive responses to the Physical Activity Readiness Questionnaire (PAR-Q) 5. Taking any medication that might interfere with the study outcomes 6. Illness/condition that might interact with study measures (e.g. diabetes, heart disease)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin sensitivity (incremental area under the curve, HOMA-IR, Matsuda index), assessed following an oral glucose tolerance test (OGTT) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The expression patterns of several key genes and proteins within adipose tissue 2. The expression patterns of several key genes and proteins within skeletal muscle 3. Various metabolic parameters assessed through blood analysis, including serum insulin, C-peptide and plasma glucose responses during an Oral Glucose Tolerance Test (OGTT). Lipid profiles including the measurement of Triglycerides, Non-esterified fatty acids (NEFA), Low-density lipoprotein cholesterol (LDLC) and High-densitylipoprotein cholesterol (HDLC) | — |
Countries
United Kingdom
Contacts
Public ContactJean-Philippe Walhin
Outcome results
None listed