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Platelet-rich plasma injections and periodontal health

Platelet-rich plasma injections and periodontal health: effects during accelerated orthodontic tooth movement

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN18306557
Enrollment
40
Registered
2024-08-30
Start date
2022-01-01
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior teeth crowding Oral Health

Interventions

Participants are randomly assigned to either the PRP group or the control group. Randomization was achieved using sealed envelopes containing the allocation sequence, ensuring that treatment assignmen

Sponsors

Tishreen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Individuals aged 18 to 25 years with anterior teeth crowding ranging from 3 to 6 mm 2. Maintaining excellent oral hygiene and periodontal health 3. Without prior orthodontic treatment history

Exclusion criteria

Exclusion criteria: 1. Systemic medical conditions 2. Dental anomalies in tooth size or shape 3. Current use of anti-inflammatory medications

Design outcomes

Primary

MeasureTime frame
Salivary aspartate aminotransferase (AST) activity measured using a spectrophotometer at baseline (before treatment), 1 hour after the start of treatment, 1 week after, and 2 weeks after treatment

Secondary

MeasureTime frame
Periodontal health parameters, including Periodontal Pocket Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP), and Gingival Recession (GR), were recorded using a UNC-15 periodontal probe at baseline, 4 weeks, 8 weeks, and 12 weeks.

Countries

Syria

Contacts

Public ContactMay Akel
akeelmai035@gmail.com+963 (0)992964458

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026