COVID-19 (SARS-CoV-2 infection) Infections and Infestations COVID-19 (SARS-CoV-2 infection)
Conditions
Interventions
Adult patients admitted to the Intensive Care Unit of Academic Hospital Paramaribo or the Wanica Regional Hospital, Suriname with severe or life-threatening COVID-19 were enrolled in the trial. After
Sponsors
Academic Hospital Paramaribo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Polymerase chain reaction (PCR) confirmed COVID-19 disease 2. Aged >18 years 3. Written informed consent to participate in the study from the patient, or legal patient representative if the patient is unconscious (spouse or 1st-degree family member, and if absent 2nd-degree family member or acquaintance) 4. Admittance to the ICU due to progressive respiratory failure ranging between severe and life-threatening ARDS based on the Berlin classification 5. Requiring non-invasive ventilation
Exclusion criteria
Exclusion criteria: 1. Requiring invasive ventilation 2. A “no ICU admission” or “no invasive ventilation” restriction in place at the time of screening for the study 3. Admitted to the COVID-19 ward but asymptomatic, admitted due to the national admission policy, or mild SARS-CoV2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day ICU mortality measured from patient records at 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Lung function measured as pulmonary oxygen exchange capacity (PF ratio) calculated from arterial blood gas and patient oxygen requirements at baseline and 2 days 2. Extent of lung abnormalities measured as chest x-ray (CXR) score calculated from CXR scans at baseline and 2 days | — |
Countries
Suriname
Contacts
Public ContactRosita Bihariesingh
Outcome results
None listed