The relationship between the microbes in the lower respiratory tract and allergic respiratory diseases in children

The relationship between the lower respiratory tract microbiome and allergic respiratory tract diseases in children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18302701

Enrollment

Registered

2020-10-06

Start date

2018-01-01

Completion date

Unknown

Last updated

2022-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic respiratory tract diseases in children Respiratory

Interventions

Nucleic acid is extracted from samples of bronchoalveolar lavage fluid (BALF) of children taken during bronchoscopy treatment and the 16S rDNA gene is sequenced and analysed.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children who visit the respiratory department and undergo bronchoscopy

Exclusion criteria

Exclusion criteria: 1. Diagnosis of pneumonia with specific pathogen infection such as fungus, virus, or mycoplasma 2. History of mechanical ventilation

Design outcomes

Primary

Measure	Time frame
The microbiome in BAFL measured using 16S rDNA sequenced on a MiSeq instrument (Illumina, Inc.) using a Miseq v2 reagent kit (Illumina, Inc.) at a single timepoint	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026