A dynamic exercise programme to improve patients' disability in rheumatoid arthritis: a prospective randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18282428

Enrollment

Registered

2008-07-21

Start date

2004-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis Musculoskeletal Diseases Other rheumatoid arthritis

Interventions

Roeder manipulative aptitude test, five-handle position grip test and grip and pinch strength test were carried out at baseline to avoid discrepancy in term of patients' skill between the two groups.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 1987 modified American College of Rheumatology (ACR) criteria for RA 2. Treated with a disease-modifying anti-rheumatic drug

Exclusion criteria

Exclusion criteria: 1. >10 mg glucocorticoid per day 2. No or unstable Disease Modifying Anti-Rheumatic Drug (DMARD) regimen 3. DAS28 variation >1.2 in the past 3 months 4. Age 70 5. Severe comorbidity causing a reduced life expectancy 6. Global functional status in RA class III or IV 7. Patients unable to follow the educational program or complete a questionnaire because of cognitive impairment, psychiatric disease, social frailty or language difficulty

Design outcomes

Primary

Measure	Time frame
Functional status, evaluated by the Health Assessment Questionnaire (HAQ) at 1 and 6 months and 1 year. HAQ total score ranges from 0 (no functional limitation) to 3 (dramatic functional impairment).	—

Secondary

Measure	Time frame
The following were assessed at 1, 6 and 12 months: 1. Functional, clinical, radiological, therapeutic and biological modifications in both groups using the following tools: 1.1. The French version of Arthritis Impact Score 2- short form (AIMS2-SF) is a specific questionnaire to assess quality of life in RA patients. AIMS2-SF was not converted to a score of 0 to 10 but was expressed on a scale from 0 to 50. 1.2. Nottingham Health Profile (NHP) is a 38 item generic health-related quality of life measure (range 0 to 600, higher score for greater health problems) 2. Patient dexterity, evaluated by occupational therapists using Sequential Occupational Dexterity Assessment (SODA) or self reported by patients using Duruoz Hand Index (DHI) and a self report questionnaire. 2.1. SODA consists of 12 standardized tasks evaluated by occupational therapists and ranges from 0 to 108. 2.2. The purpose of DHI (range 0-90) was to measure hand ability while performing personal hygiene, office tasks and other general activities 3. Simple Erosions Narrowing Score (SENS, range 0-86) considers erosions in 32 joints in the hands and 12 in the feet, and joint space narrowing in 30 and 12 joints respectively. The total SENS score was assessed by a single radiologist unaware of the group assignment. 4. Disease activity was determined using Disease Activity Score (DAS 28, range 0.14-9.3). A 28 joint count for swelling and tenderness was assessed by a rheumatologist unaware of the treatment allocation. Patients rated their general health on a 100 mm visual analogue scale. DAS 28 was calculated using the three previously mentioned parameters and Erythrocyte Sedimentation Rate (ESR). 5. Aerobic capacity was measured on an exercise bike as the distance covered in 5 minutes. 6. Use of oral and intra-articular drug, as well as other medical devices were recorded	—

Measure

Time frame

The following were assessed at 1, 6 and 12 months: 1. Functional, clinical, radiological, therapeutic and biological modifications in both groups using the following tools: 1.1. The French version of Arthritis Impact Score 2- short form (AIMS2-SF) is a specific questionnaire to assess quality of life in RA patients. AIMS2-SF was not converted to a score of 0 to 10 but was expressed on a scale from 0 to 50. 1.2. Nottingham Health Profile (NHP) is a 38 item generic health-related quality of life measure (range 0 to 600, higher score for greater health problems) 2. Patient dexterity, evaluated by occupational therapists using Sequential Occupational Dexterity Assessment (SODA) or self reported by patients using Duruoz Hand Index (DHI) and a self report questionnaire. 2.1. SODA consists of 12 standardized tasks evaluated by occupational therapists and ranges from 0 to 108. 2.2. The purpose of DHI (range 0-90) was to measure hand ability while performing personal hygiene, office tasks and other general activities 3. Simple Erosions Narrowing Score (SENS, range 0-86) considers erosions in 32 joints in the hands and 12 in the feet, and joint space narrowing in 30 and 12 joints respectively. The total SENS score was assessed by a single radiologist unaware of the group assignment. 4. Disease activity was determined using Disease Activity Score (DAS 28, range 0.14-9.3). A 28 joint count for swelling and tenderness was assessed by a rheumatologist unaware of the treatment allocation. Patients rated their general health on a 100 mm visual analogue scale. DAS 28 was calculated using the three previously mentioned parameters and Erythrocyte Sedimentation Rate (ESR). 5. Aerobic capacity was measured on an exercise bike as the distance covered in 5 minutes. 6. Use of oral and intra-articular drug, as well as other medical devices were recorded

—

Countries

France

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026