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Dynamic diaphragm function trajectory via ultrasound predicts weaning outcomes in mechanically ventilated patients

Dynamic diaphragm function trajectory via ultrasound predicts weaning outcomes in mechanically ventilated patients: the diaphragm-protective ventilation (DMV) study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN18266820
Enrollment
1000
Registered
2026-03-11
Start date
2026-03-30
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dynamically monitor diaphragmatic function in mechanically ventilated patients in the intensive care unit (ICU) using point-of-care ultrasound, explore its trajectory, and evaluate its predictive value for weaning outcomes. Respiratory

Interventions

This is a prospective cohort study to dynamically assess diaphragmatic function using bedside ultrasound to predict weaning outcomes in mechanically ventilated patients. During the study, researchers

Sponsors

First Affiliated Hospital of Jinan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 120 Years

Inclusion criteria

Inclusion criteria: 1. Age = 18 years old 2. Intubated orally or nasotracheal with invasive mechanical ventilation 3. Expected duration of mechanical ventilation > 48 hours 4. Informed consent was obtained from their legal representatives of patients

Exclusion criteria

Exclusion criteria: 1. Previous known diaphragmatic disease or paralysis (e.g., cervical spinal cord injury, amyotrophic lateral sclerosis, etc.) 2. Previous history of thoracic surgery, especially involving the diaphragm or lung resection, may severely affect diaphragmatic anatomy 3. Use of neuromuscular blocking agents 4. History of chronic obstructive pulmonary disease 5. Pregnant women 6. Technical difficulties in surface ultrasound examination (e.g., severe subcutaneous emphysema, extreme obesity) 7. Other conditions considered by the investigator to be inappropriate for inclusion (e.g., terminal state, treatment withdrawal).

Countries

China

Contacts

Public ContactWan-Jie Gu
guwanjie@jnu.edu.cn+86 15850546835

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026