Research on key technologies for perioperative risk management and control of age-related diseases

Research on key technologies for perioperative risk management in elderly patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18251692

Enrollment

2000

Registered

2024-05-08

Start date

2022-01-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative blood pressure management in elderly patients with hypertension Circulatory System

Interventions

In this study, the influence of mean arterial pressure (MAP)-guided perioperative blood pressure management mode on the outcome of elderly hypertensive patients will be explored. This experiment calcu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Elderly patients, aged 65-80 years old 2. Patients with a history of hypertension with systolic blood pressure =140mmHg and pulse pressure difference =60mmHg 3. No contraindications to anesthesia 4. No signs of systemic infection

Exclusion criteria

Exclusion criteria: 1. Tumors in other locations 2. A history of long-term use of sedative and analgesic drugs 3. Uncontrollable hypertension 4. Hyperglycemia 5. Severe liver and kidney dysfunction 6. Other contraindications for surgery

Design outcomes

Primary

Measure	Time frame
1. Blood pressure level measured using the cuff three times a day, three days, one week and one month after surgery 2. Pain measured using a Visual Analog Scale (VAS) on the day, three days and one week after surgery 3. Body function and cognition measured using the unified standard rating scale after the operation 4. Rehabilitation will be measured by Specialists to establish a unified standard of physical examination to judge the rehabilitation of patients after the operation 5. Surgical complications, incidence of target organ injury (stroke, acute coronary syndrome, kidney injury), average length of stay, ICU transfer rate, and postoperative outcomes measured using data collected in patient medical records on the day, three days, one week, and one month after surgery	—

Measure

Time frame

1. Blood pressure level measured using the cuff three times a day, three days, one week and one month after surgery 2. Pain measured using a Visual Analog Scale (VAS) on the day, three days and one week after surgery 3. Body function and cognition measured using the unified standard rating scale after the operation 4. Rehabilitation will be measured by Specialists to establish a unified standard of physical examination to judge the rehabilitation of patients after the operation 5. Surgical complications, incidence of target organ injury (stroke, acute coronary syndrome, kidney injury), average length of stay, ICU transfer rate, and postoperative outcomes measured using data collected in patient medical records on the day, three days, one week, and one month after surgery

—

Secondary

Measure	Time frame
1. Perioperative stress indexes (blood glucose and cortisol) and inflammatory indexes (IL-6, TNF-a and C-reactive protein) measured using standard tests in venous blood samples before surgery, on the day after surgery, and on the second and third days after surgery, respectively, at 8 pm 2. Target organ function indicators (myocardial enzyme profile, urea nitrogen, creatinine, NSE and S100ß) measured using standard tests in venous blood samples at 8 pm on the first day, three days and one week after surgery	—

Measure

Time frame

1. Perioperative stress indexes (blood glucose and cortisol) and inflammatory indexes (IL-6, TNF-a and C-reactive protein) measured using standard tests in venous blood samples before surgery, on the day after surgery, and on the second and third days after surgery, respectively, at 8 pm 2. Target organ function indicators (myocardial enzyme profile, urea nitrogen, creatinine, NSE and S100ß) measured using standard tests in venous blood samples at 8 pm on the first day, three days and one week after surgery

—

Countries

China

Contacts

Public ContactYankai Ma

531571201@qq.com+86 18799158127

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026