Ethnic differences in type 2 diabetes pathophysiology

Exploring ethnic differences in the pathophysiological response to a low-energy diet in people with type 2 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18241480

Enrollment

Registered

2026-02-27

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes - Type 2 Nutritional, Metabolic, Endocrine

Interventions

Baseline assessments (before the diet starts) Participants attend two detailed assessment visits. These include measurements of weight, body composition, blood sugar levels, scans to measure body and

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 40–65y 2. BMI 27–45kg/m² 3. Diagnosed with T2D within the last 6 years 4. HbA1c value >43mmol/mol,if <48mmol/mol individuals should still be receiving antidiabetic medication (mono or dual therapy) 5. Willing and able to consent to participate in the trial 6. Able to understand written and spoken English

Exclusion criteria

Exclusion criteria: 1. Current use of insulin 2. HbA1c =87 mmol/mol 3. Weight loss of >3kg within the past 6 months 4. eGFR of <30 mL/min/m² 5. Heart failure 6. Participation in another clinical interventional trial 7. Substance abuse 8. Known cancer 9. Myocardial infarction within previous 6 months 10. Current treatment with anti-obesity drugs 11. Pregnancy (or consideration of) 12. Use of antipsychotic drugs

Countries

United Kingdom

Contacts

Public ContactGráinne Whelehan

g.whelehan@leicester.ac.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026