Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

Exploring cerebral structural alterations using MRI and determining their association with clinical parameters in Idiopathic rapid eye movement sleep behavior disorder (iRBD) patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18238599

Enrollment

Registered

2018-10-24

Start date

2014-03-06

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic rapid eye movement sleep behavior disorder Mental and Behavioural Disorders Idiopathic rapid eye movement (REM) sleep behavior disorder

Interventions

All iRBD patients underwent one night (8 hours) of audio-video-PSG monitoring. All MRI measurements were obtained on a 3-tesla GE Discovery MR750 Scanner for ~30minutes. Brain structural T1-weighted M

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18–65 years 2. Diagnosed with iRBD according to the clinical and polysomnographic (PSG) characteristics

Exclusion criteria

Exclusion criteria: 1. Signs of parkinsonism 2. Treated with psychotropic medications 3. Evidence of psychiatric disorders or dementia 4. Any cognitive impairment 5. Drug-induced iRBD 6. Sleep apnea syndrome 7. Electroencephalograph (EEG) abnormalities suggestive of epilepsy, central nervous system comorbidities such as brain tumor, encephalitis, unstable hypertension, and diabetes

Design outcomes

Primary

Measure	Time frame
Gray matter volume, assessed by MRI scans for 30 minutes at the study visit	—

Secondary

Measure	Time frame
Polysomnography monitoring over one night for 8 hours to assess: 1. Total sleep duration 2. Sleep efficiency 3. Stage 1 non-rapid eye movement (NREM) 4. Stage 2 NREM 5. Rapid eye movement sleep time 6. Apnea-hypopnea index 7. Phasic electromyography (EMG) activity index 8. Tonic EMG activity 9. Spontaneous microarousal index 10. Periodic limb movements in sleep	—

Countries

China

Contacts

Public ContactXian-Hua Han

xhhan_2015@126.com+86 (0)15802117087

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 22, 2026