Investigating the effects of icing on pain duration after wisdom tooth extraction

Investigating pain duration after cryotherapy: a parallel randomized controlled trial of postoperative third molar extraction treatment

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18223654

Enrollment

200

Registered

2025-11-06

Start date

2025-11-21

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-surgical pain and inflammation after wisdom tooth extraction Oral Health

Interventions

Randomization: will be done 1-2 days before the wisdom tooth extraction through a computer-generated list with randomly permuted blocks of 2, 4, 6, and 8. Cryotherapy Treatment: participants will be

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. 18+ years old 2. Normal healthy patients (ASA I) and patients with mild systemic disease (e.g., asthma) (ASA II) 3. Need at least one wisdom tooth removed after an x-ray assessment

Exclusion criteria

Exclusion criteria: 1. History of chronic pain or chronic orofacial pain 2. History of chronic analgesic use 3. Known contraindication to cryotherapy (e.g., cold allergy, cold hypersensitivity, cold urticaria, Raynaud’s disease) 4. Known contraindication to acetaminophen (e.g., hypersensitivity to acetaminophen, active liver disease or impairment) 5. Current smoking habit or smoking more than 5 times per week (e.g., cigarettes, e-cigarettes, vaping, cannabis)

Design outcomes

Primary

Measure	Time frame
Pain duration (time-to-event outcome; amount of time it takes for pain intensity to reach the first 0 at any time point that isn’t followed by a non-0 pain rating), measured using a digital adaptation of the 10-cm pain visual analog scale (VAS) (with 0 being “no pain” and 10 being “worst pain imaginable”) over 14 days post-surgery (23 assessments total: baseline, surgery day (day 0), and post-surgery (2x/day for days 1-7, and 1x/day for days 8-14)).	—

Measure

Time frame

Pain duration (time-to-event outcome; amount of time it takes for pain intensity to reach the first 0 at any time point that isn’t followed by a non-0 pain rating), measured using a digital adaptation of the 10-cm pain visual analog scale (VAS) (with 0 being “no pain” and 10 being “worst pain imaginable”) over 14 days post-surgery (23 assessments total: baseline, surgery day (day 0), and post-surgery (2x/day for days 1-7, and 1x/day for days 8-14)).

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Secondary

Measure	Time frame
1. Pain intensity measured using a digital adaptation of adaptation of the 10-cm pain visual analog scale (VAS) over 14 days 2. Pain relief usage measured using self-report questionnaires over 14 days 3. Rescue medication usage measured using self-report questionnaires over 14 days 4. Post-surgical third molar oral health outcomes measured with the Oral Health-Related Quality of Life Instrument over 14 days.	—

Measure

Time frame

1. Pain intensity measured using a digital adaptation of adaptation of the 10-cm pain visual analog scale (VAS) over 14 days 2. Pain relief usage measured using self-report questionnaires over 14 days 3. Rescue medication usage measured using self-report questionnaires over 14 days 4. Post-surgical third molar oral health outcomes measured with the Oral Health-Related Quality of Life Instrument over 14 days.

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Countries

Canada

Contacts

Public ContactJeffrey S. Mogil

jeffrey.mogil@mcgill.ca+1 (514) 398-6085

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026