Osteonecrosis of the femoral head at early stage Musculoskeletal Diseases Osteonecrosis
Conditions
Interventions
Osteonecrosis of the femoral head remains a significant health concern. Currently, core decompression combined with implantation of autologous bone marrow mononuclear cells appears to be an effective
Sponsors
Dalian University Zhongshan Hospital (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 18 to 45 years, either sex 2. Patients with hips at stages IC to IIC according to Association Research Circulation Osseous (ARCO) classification 3. Etiological factors including trauma, alcohol abuse, corticosteroid use, Caisson disease, hyperlipidemia, and idiopathic
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Current and previous infection 3. Skeletal immaturity 4. Immunosuppressive drug therapy 5. A history of inflammatory arthritis 6. Evidence of cardiovascular diseases 7. Prior systemic corticosteroid treatment 8. Mental health problems preventing adequate follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical outcome, assessed by the Harris Hip Score, measured pre-operatively and at 3 months, 6 months, 12 months, 30 months, and every 2 years post-operatively thereafter | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiographic approaches are used to determine the progress in osteonecrotic stage and to assess the volume of the necrotic lesion in the femoral head, measured pre-operatively and at 3 months, 6 months, 12 months, 30 months, and every 2 years post-operatively thereafter | — |
Countries
China
Outcome results
None listed