Specialty: Dementia and Neurodegeneration, Primary sub-specialty: Dementia
Conditions
Interventions
This study is a feasibility study and will follow a longitudinal design using serial 7Li-MRI and structural MRI sequences.
Participant recruitment:
This study will recruit up to 20 subjects: 12 parti
MMSE score 16-24) and 8 healthy volunteers (matched on age and sex).
Study design:
The study will proceed in 2 phases.
In study phase 1:
Up to 4 people with Alzheimers disease will be recruited to c
Sponsors
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Healthy subjects 1. Aged 50-80 years old 2. No history of past or present major psychiatric or neurological disorders or mild cognitive impairment Patients only 1. Aged 50-80 years old 2. Diagnosis of Alzheimer’s disease – made by two independent clinicians based on McKhann criteria 3. Mild-moderate disease severity (Mini- Mental State Examination score 16-24) 4. No history of bipolar disorder, major depression or other neuropsychiatric conditions aside from Alzheimer’s disease
Exclusion criteria
Exclusion criteria: 1. Presence of contraindications to lithium treatment (such as renal failure, epilepsy or psoriasis) 2. Presence of contraindications to magnetic resonance imaging (such as pacemakers and other incompatible implants, claustrophobia) 3. Current treatment with lithium, non-steroidal anti-inflammatory drugs or ACE inhibitors 4. Lack of sufficient understanding of the nature of the study and any hazards of participating in it 5. Lack of ability to communicate satisfactorily with the investigator and to participate in, and comply with the requirements of, the entire study 6. Lack of willingness to give written consent to participate after reading the information and consent forms, and after having the opportunity to discuss the study with the investigator or his delegate 7. Lack of capacity to provide informed consent, as judged by an investigator
Countries
England, United Kingdom
Contacts
Public ContactDavid Cousins
Outcome results
None listed