Exercise-induced bronchoconstriction Respiratory
Conditions
Interventions
In total, participants will visit on 6 occasions which include the following visits:
Visit 1 - Confirmation of group (indirect bronchoprovocation test - see below for further detail)
Visit 2 - VO2 max
Sponsors
University of Kent
Eligibility
Sex/Gender
Male
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Ability to consent to the research 2. Aged 18 to 55 years old 3. Physically active (defined as engaging in at least 75 minutes of high intensity exercise a week) 4. Either a diagnosis of Exercise-Induced Bronchoconstriction or without a diagnosis 5. Normal resting Forced Expiratory Volume in One Second (FEV1) defined as >80% predicted value.
Exclusion criteria
Exclusion criteria: 1. Respiratory infection or hospitalisation related to respiratory conditions in the last 4 weeks 2. Respiratory condition other than an asthma-related condition 3. Chronic medical conditions (e.g., metabolic, neurological, cardiovascular etc)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Exercise performance measured using one 5km cycling time trial assessed by completion time. This will be done following a single 1L of the drink (acute) and following 2 weeks of drinking 1L a day of the drink (chronic). 2. Urine levels of 9a,11ß-prostaglandin and Clara cell protein (CC16) measured in venous blood samples collected at the end of the two weeks of each water condition using enzyme-linked immunosorbent assay (ELISA) method at baseline of that final visit. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether hydrogen-rich water improves exercise performance and/or the physiological response to exercise, the following measures will be taken: 1. Gas exchange (VO2, VCO2) measured using a respiratory gas analyser at each 1km of the 5km time trials 2. Perceptual responses measured using the Borg Rating of Perceived Exertion (RPE) scale at each 1km of the 5km time trials 3. Heart rate measured using a heart rate Bluetooth chest band at each 1km of the 5km time trial 4. Blood lactate concentration measured using finger prick blood samples before and after each 5km time trial To determine whether hydrogen-rich water improves lung function, the following outcome variable will be assessed: Lung function measured using spirometry following participants drinking 1 litre of water and following 2 weeks (1 litre of water a day) | — |
Countries
England, United Kingdom
Contacts
Public ContactSavannah Sturridge
Outcome results
None listed