Mild Alzheimer’s disease (mild AD), mild cognitive impairment (MCI) Nervous System Diseases Alzheimer disease
Conditions
Interventions
Participants undergo a cognitive assessment using both the ICA and the Montreal cognitive assessment (MoCA) at baseline. A blood sample will also be taken to measure the level of amyloid-beta, p-Tau,
Sponsors
Cognetivity Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Capacity to understand the information about the study and to give consent to participate 2. Males and females aged between 50-90 years 3. Not currently on medication that may interfere with the study results 4. Healthy individuals; or individuals with specialist diagnosis of mild cognitive impairment or mild AD according to NINCDS-ADRDA criteria
Exclusion criteria
Exclusion criteria: 1. Presence of significant cerebrovascular disease 2. Major medical co-morbidities e.g. Congestive Cardiac Failure, Diabetes Mellitus with renal impairment 3. Major psychiatric disorder eg. Chronic psychosis, recurrent depressive disorder, generalized anxiety disorder 4. The use of cognitive-enhancing drugs e.g. cholinesterase inhibitors, unless on stable doses 5. A concurrent diagnosis of epilepsy 6. A history of alcohol misuse 7. A history of illicit drug use 8. A history of severe visual impairment, e.g. macular degeneration, diabetic retinopathy, as determined by the clinical team 9. A history of TBI 10. Presence of sleep apnoea
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Serum amyloid-beta 40 and amyloid-beta 42 levels measured using ELISA test at baseline 2. Serum Phosphorylated Tau level measured using ELISA test at baseline 3. Serum Neurofilament light-chain (NFL) levels measured using ELISA test at baseline 4. Level of cognitive performance measured by ICA test at baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. APOE genotype determined by DNA sequencing at baseline 2. Level of cognitive performance measured by MoCA test at baseline | — |
Countries
Iran
Outcome results
None listed